| 货号 | 21857-10mg |
| 描述 | 6-hydroxy Melatonin is the primary active metabolite of melatonin (Item No. 14427). 6-hydroxy Melatonin acts as an agonist at the melatonin 1 (MT1) and MT2 receptors, with approximately the same potency as melatonin in a competition assay using [3H]-melatonin and human recombinant receptors (pKi = 9.23 and 9.93, respectively for MT1; 8.79 and 9.65, respectively for MT2).1 Melatonin is an indoleamine neurohormone whose levels vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions in animals, plants, and microbes.2 Melatonin also has antioxidative properties, but 6-hydroxy melatonin is a better scavenger of reactive oxygen species than melatonin in rat brain homogenates.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Dubocovich, M.L. Melatonin receptors: Are there multiple subtypes? Trends Pharamacol. Sci. 16(2), 50-56 (1995). 2.Boutin, J.A.,Audinot, V.,Ferry, G., et al. Molecular tools to study melatonin pathways and actions. Trends in Pharamacological Sciences 26(8), 412-419 (2005). 3.Alvarez-Diduk, R.,Galano, A.,Tan, D.X., et al. N‑Acetylserotonin and 6‑hydroxymelatonin against oxidative stress: Implications for the overall protection exerted by melatonin. J. Phys. Chem. B 119(27), 8535-8543 (2015). 4.Maharaj, D.S.,Walker, R.B.,Glass, B.D., et al. 6-Hydroxymelatonin protects against cyanide induced oxidative stress in rat brain homogenates. J. Chem. Neuroanat. 26(2), 103-107 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 248.3 |
| 分子式 | C13H16N2O3 |
| CAS号 | 2208-41-5 |
| 稳定性 | ≥ 2 years |
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