MIRA-1
货号：
14858-50mg 基本售价：
4354.0 元 规格：
50 mg
产品信息
概述| 货号 | 14858-50mg |
| 描述 | MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).1 Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.1 At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone (Item No. 11015), arrested tumor growth in a mouse xenograft model of multiple myeloma.2 |
| 别名 | NSC 19630; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bykov, V.J.N.,Issaeva, N.,Zache, N., et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. The Journal of Biological Chemisty 280(34), 30384-30391 (2005).
2.Saha, M.N.,Chen, Y.,Chen, M.H., et al. Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. British Journal of Cancer 110(9), 2224-2231 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥99% |
| 计算分子量 | 183.2 |
| 分子式 | C8H9NO4 |
| CAS号 | 72835-26-8 |
| 稳定性 | ≥ 1 year |
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