| 货号 | 5651/10 |
| 别名 | 5-Amino-N-[1-[[5-(1,1-dimethylethyl |
| 供应商 | Tocris |
| 生物活性 | High affinity and selective human neutrophil elastase 1 (HNE1) inhibitor (Ki = 12 nM). Exhibits >100-fold less activity at other related proteases including trypsin, pancreatic elastase, collagenase and murine macrophage elastase. Inhibits HNE-induced lung hemorrhaging and suppresses leukocyte levels in an in vivo model of COPD. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 452.51 |
| 分子式 | C23H28N6O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Stevenset al (2011) AZD9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J.Pharmacol.Exp.Ther. 339 313. PMID: 21791628. Hirotaet al (2004) Effects of the neutrophil elastase inhibitor (ONO-6818) on acetic acid induced colitis in Syrian hamsters. J.Vet.Med.Sci. 66 1223. PMID: 15528853. Aoshibaet al (2001) Serine proteases increase oxidative stress in lung cells. Am.J.Physiol.Lung Cell Mol.Physiol. 281 556. PMID: 11504681. |