Ubiquitin Isopeptidase Inhibitor I
货号:
21006-25mg 基本售价:
4200.0 元 规格:
25 mg
产品信息
概述货号 | 21006-25mg |
描述 | Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC50 = ~1.7 µM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC50 = ~30 µM).1 It has also been shown to induce necrosis in apoptosis-resistant DKO cells.2 |
别名 | NSC 144303; |
性能供应商 | Cayman |
应用文献 |
1.Aleo, E.,Henderson, C.J.,Fontanini, A., et al. Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis. Cancer Research 66(18), 9235-9244 (2006). 2.Fontanini, A.,Foti, C.,Potu, H., et al. The isopeptidase inhibitor G5 triggers a caspase-independent necrotic death in cells resistant to apoptosis: A comparative study with the proteasome inhibitor bortezomib. J. Biol. Chem. 284(13), 8369-8381 (2009).
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运输条件 | Wet ice in continental US; may vary elsewhere |
存放说明 | -20 |
纯度 | ≥98% |
计算分子量 | 414.4 |
分子式 | C19H14N2O7S |
CAS号 | 108477-18-5 |
稳定性 | ≥ 2 years |
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