| 货号 | 11178-50ug |
| 描述 | DPY-30 is a component of the MLL1 methylation complex, which interacts directly with Ash2L.1InC. elegans, DPY-30 is required for dosage compensation in XX individuals, and its deletion or mutation is lethal. For XO individuals, DPY-30 is required for proper growth and development.2,3 DPY-30 is a homodimer in solution, and two monomers interact with one Ash2L monomer.4 Addition of DPY-30 to the MLL1, WDR5, RbBP5, and Ash2L complex results in a 2-fold increase in methylation rate, from 300x the MLL1 basal rate to 600x the MLL1 basal rate.5 |
| 别名 | DPY-30-like protein;hDPY-30;SAF19; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.South, P.F.,Fingerman, I.M.,Mersman, D.P., et al. A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression. The Journal of Biological Chemisty 285(1), 595-607 (2010). 2.Hsu, D.R. and Meyer, B.J. The dpy-30 gene encodes an essential component of the Caenorhabditis elegans dosage compensation machinery. Genetics 137, 999-1018 (1994). 3.Hsu, D.R.,Chuang, P.T. and Meyer, B.J. DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation. Development 121(10), 3323-3334 (1995). 4.Patel, A.,Dharmarajan, V.,Vought, V.E., et al. On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. The Journal of Biological Chemisty 284(36), 24242-24256 (2009). 5.Mohan, M.,Lin, C.,Guest, E., et al. Licensed to elongate: A molecular mechanism for MLL-based leukaemogenesis. Nature Reviews.Cancer 10(10), 721-728 (2010). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 稳定性 | ≥ 6 months |
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