12-Lipoxygenase (platelet-type, mouse recombinant)
货号：
10341-25ug 基本售价：
4200.0 元 规格：
25 ug
产品信息
概述| 货号 | 10341-25ug |
| 描述 | 12-Lipoxygenase (12-LO) catalyzes the formation of 12-HpETE from arachidonic acid.1 There are two main types of 12-LO, platelet-type and leukocyte-type, which share only 60% identity at the amino acid level and strongly differ in substrate specificity and enzyme kinetics.2 Leukocyte-type 12-LO has the ability to also produce 15-HpETE, however, platelet-type predominately forms 12-HpETE.2 Epidermal-type 12(S)- and 12(R)-LO enzymes have also been characterized, which catalyze the synthesis of their respective stereospecific 12-HETE products.2,3 |
| 别名 | Arachidonate 12-Lipoxygenase;12-LO;12-LOX; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chen, X.S.,Kurre, U.,Jenkins, N.A., et al. cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases. The Journal of Biological Chemisty 269, 13979-13987 (1994).
2.McDonnell, M.,Davis, W., Jr.,Li, H., et al. Characterization of the murine epidermal 12/15-lipoxygenase. Prostaglandins & Other Lipid Mediators 63, 93-107 (2001).
3.McDonnell, M.,Li, H. and Funk, C.D. Characterization of epidermal 12(S) and 12(R) lipoxygenase. Eicosanoids & other bioactive lipids in cancer, inflammation & radiation injury 5, 147-153 (2002).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 6 months |
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