| 货号 | 19881-50ug |
| 描述 | Annexins are a superfamily of 13 proteins sharing a high degree of homology. They have in common a core C-terminal domain containing calcium and phospholipid binding motifs, allowing most of them to bind to phospholipid membranes in a calcium-dependent manner. The N-terminal domains vary between family members and provide unique a function.1 Annexin A1 is an endogenous mediator of inflammation, promoting resolution in a number of ways. Normally expressed in intracellular compartments, it is drawn to the cell membrane and both induced and externalized by glucocorticoid response pathways.2,3 The glucocorticoid-induced production and release of annexin A1 is the primary means by which glucocorticoids function as anti-inflammatory agents. Annexin A1 inhibits the synthesis of pro-inflammatory eicosanoids by suppressing the function of sPLA2. This, in turn, limits the recruitment of neutrophils into inflammatory sites and downregulates the production of pro-inflammatory mediators by those neutrophils that enter inflammatory sites.4 Meanwhile, proteolytic fragments generated in response to increased expression are implicated in producing a marker for phagocytosis.5 Annexin A1 also functions in the resolution of inflammation by inducing neutrophil apoptosis, and promoting neutrophil clearance (efferocytosis) by macrophages. The pro-resolving functions of annexin A1 are mediated via binding to FPR2/ALX, a receptor it shares with the specific pro-resolving mediators lipoxin A4 (Item No. 90410) and resolvin D1 (Item No. 10012554).4 The molecule’s regulatory role has led to investigation of the downstream effects of annexin A1, including cancer, adaptive immunity, and wound repair.6,7,8 |
| 别名 | p35;Annexin I;ANXA1;Calpactin II;Lipocortin I; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gerke, V., and Moss, S.E. Annexins: From structure to function. Physiological Reviews 2002, 331-371 (2002). 2.Damazo, A.S.,Yona, S.,Flower, R.J., et al. Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. Journal of Immunology 176(7), 4410-4418 (2006). 3.Perretti, M.,Croxtall, J.D.,Wheller, S.K., et al. Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigration. Nature Medicine 2(11), 1259-1262 (1996). 4.Sugimoto, M.A.,Vago, J.P.,Teixeira, M.M., et al. Annexin A1 and the resolution of inflammation: Modulation of neutrophil recruitment, apoptosis, and clearance. J.Immunol.Res. 2016:8239258, (2016). 5.Christmas, P.,Callaway, J.C.,Fallon, J., et al. Selective secretion of annexin 1, a protein without a signal sequence, by the human prostate gland. The Journal of Biological Chemisty 266(4), 2499-2507 (1991). 6.Boudhraa, Z.,Bouchon, B.,Viallard, C., et al. Annexin A1 localization and its relevance to cancer. Clin.Sci.(Lond) 130(4), 205-220 (2016). 7.DAcquisto, F.,Merghani, A.,Lecona, E., et al. Annexin-1 modulates T-cell activation and differentiation. Blood 109(3), 1095-1102 (2007). 8.Leoni, G.,Neumann, P.A.,Kamaly, N., et al. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. Journal of Clinical Investigation 125(3), 1215-1227 (2015). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% (estimated by SDS-PAGE) |
| 稳定性 | ≥ 1 year |
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