| 货号 | 4188/10 |
| 别名 | 3-(Aminocarbonyl)-β-(3-cyclohexylpro |
| 供应商 | Tocris |
| 生物活性 | Potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 324.38 |
| 分子式 | C15H24N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Baileyet al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562. PMID: 18945617. Fishet al (2007) Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 50 3442. PMID: 17591762. Allanet al (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 36 399. PMID: 16854779. |