PF 184 (10 MG)
货号：
4238/10 基本售价：
4154.1 元 规格：
10 mg
产品信息
概述| 货号 | 4238/10 |
| 别名 | 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective IKKβ inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 619.09 |
| 分子式 | C32H32ClFN6O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Sommerset al (2009) Novel tight-binding inhibitory factor-κB kinase (IKK-2) inhibitors demostrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. J.Pharmacol.Exp.Ther. 330 377. PMID: 19478133. |
