| 货号 | 2514/10 |
| 别名 | N-[[4'-[[3-Butyl-1,5-dihydro-5-oxo-1 |
| 供应商 | Tocris |
| 生物活性 | EP4 receptor antagonist that is selective over all other members of the prostanoid receptor family (Ki values are 0.024, 0.71, 1.90, 5.10, 5.63, 6.74, 19 and 23 μM for human EP4, TP, EP3, DP, FP, IP, EP1 and EP2 receptors respectively). Suppresses PGE2-induced bone formation in rats and prevents the nociceptive response induced by misoprostol in formalin-injected mice. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 654.72 |
| 分子式 | C32H29F3N4O4S2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 147776-06-5 |
| 参考文献 | Balzaryet al (2006) Lipopolysaccharide induces epithelium- and prostaglandin E2-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2. J.Pharmacol.Exp.Ther. 317 806. PMID: 16464966. Olivaet al (2006) Role of periaqueductal grey prostaglandin receptors in formalin-induced hyperalgesia. Eur.J.Pharmacol. 530 40. PMID: 16360148. Machwateet al (2001) Prostaglandin receptor EP4 mediates the bone anabolic effects of PGE2. Mol.Pharmacol. 60 36. PMID: 11408598. |