| 货号 | 2570/1 |
| 供应商 | Tocris |
| 生物活性 | Potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1302.45 |
| 分子式 | C63H83N17O14 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 374675-21-5 |
| 序列号 | YNWNSFGLRF (Modifications: Phe-10 = C-terminal amide) |
| 参考文献 | Peilecka-Fortunaet al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol. Endocrinology 149 1979. PMID: 18162521. Beckeret al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326677. Kotaniet al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631. PMID: 11457843. |