| 货号 | 5189/10 |
| 别名 | 3-[[3-[(Cyclopropylamino)sulfonyl]- |
| 供应商 | Tocris |
| 生物活性 | Potent, selective lactate dehydrogenase A (LDHA) inhibitor (IC50 values are 1.9 and 14 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 649.62 |
| 分子式 | C31H25F2N5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Xieet al (2014) Targeting lactate dehydrogenase-A inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell.Metab. 19 795. PMID: 24726384. Billiardet al (2013) Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells. Cancer Metab. 1 19. PMID: 24280423. |