| 货号 | 2983/10 |
| 别名 | (2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indo |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (Ki = 0.4 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 388.46 |
| 分子式 | C20H28N4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Shichiet al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701. PMID: 21602423. Chaoet al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49. PMID: 17678888. Grobelnyet al (1992) Inhibition of skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152. PMID: 1322694. |