CCT 241533 dihydrochloride (10 MG)
货号：
4968/10 基本售价：
4154.1 元 规格：
10 mg
产品信息
概述| 货号 | 4968/10 |
| 别名 | (3R,4S)-4-[[2-(5-Fluoro-2-hydroxyphenyl)-6,7-dimethoxy-4-quinazolinyl]amino]-α,α-dimethyl-3-pyrrolidinemethanol dihydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radiation-induced apoptosis of mouse thymocytes. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 515.41 |
| 分子式 | C23H27FN4O4< |
| 可溶性/溶解性 | Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO |
| 参考文献 | Caldwellet al (2011) Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J.Med.Chem. 54 580. PMID: 21186793. |
