| 货号 | 3874/10 |
| 别名 | (2'Z,3'E)-6-Bromoindirubin-3'-acetoxim |
| 供应商 | Tocris |
| 生物活性 | Selective GSK-3α/β inhibitor (IC50 values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). Induces Wnt signaling and inhibits CD8+ T cell effector differentiation. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 398.21 |
| 分子式 | C18H12BrN3O3 |
| 可溶性/溶解性 | Soluble to 20 mM in DMSO |
| CAS号 | 667463-85-6 |
| 参考文献 | Gattinoniet al (2009) Wnt signaling arrests T cell differentiation and generates CD8+ memory stem cells. Nat.Med. 15 808. PMID: 19525962. Polychronopouloset al (2004) Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases. J.Med.Chem. 47 935. PMID: 14761195. Meijeret al (2003) GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem.Biol. 10 1255. PMID: 14700633. |