| 货号 | 2707/10 |
| 别名 | N-[(1R)]-4-[(Aminoiminomethyl)amino |
| 供应商 | Tocris |
| 生物活性 | Mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 701.61 |
| 分子式 | C27H31N5O3.CF3CO2H |
| 可溶性/溶解性 | Soluble to 10 mM in water with sonication and to 100 mM in DMSO |
| CAS号 | 159013-54-4 |
| 参考文献 | Fanget al (2006) In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor antagonist. Peptides 27 2207. PMID: 16762456. Mollereauet al (2001) Agonist and antagonist activities on human NPFF2 receptors of the NPY ligands GR231118 and BIBP3226. Br.J.Pharmacol. 133 1. PMID: 11325787. Kasket al (1996) Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur.J.Pharmacol. 317 R3. PMID: 8997632. |