| 货号 | 2151/10 |
| 别名 | 1,5-Dihydro-5-methyl-1-β-D-ribofuran |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3β and AFX. Induces apoptosis and growth arrest in vitro, preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 320.31 |
| 分子式 | C13H16N6O4 |
| 可溶性/溶解性 | Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO |
| CAS号 | 35943-35-2 |
| 参考文献 | Yanget al (2004) Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumour activity in cancer cells overexpressing Akt. Cancer Res. 64 4394. PMID: 15231645. Ptaket al (1998) Phosphorylation of triciribine is necessary for activity against HIV type 1. AIDS Res.Hum.Retroviruses. 14 1315. PMID: 9788672. Wotringet al (1990) Dual mechanisms of inhibition of DNA synthesis by triciribine. Cancer Res. 50 4891. PMID: 2379153. |