| 货号 | 1624/10 |
| 别名 | 2-(Methylthio)adenosine-5'-(trihydro |
| 供应商 | Tocris |
| 生物活性 | Potent purinergic agonist displaying selectivity for P2Y1, P2Y12 and P2Y13 receptors (pEC50 = 8.29 and 9.05 for P2Y1 and P2Y12, EC50 = 19 nM for P2Y13). Induces aggregation of, and inhibits cAMP accumulation in, platelets in vitro. |
| 运输条件 | Dry Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 539.24 |
| 分子式 | C11H14N5Na3< |
| 可溶性/溶解性 | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
| 参考文献 | Sak and Webb (2002) A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch.Biochem.Biophys. 397 131. PMID: 11747319. Zhanget al (2002) P2Y13: identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J.Pharmacol.Exp.Ther. 301 705. PMID: 11961076. Macfarlaneet al (1983) 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J.Clin.Invest. 71 420. PMID: 6298277. |