| 货号 | 3907/10 |
| 别名 | (3β,25R)-Cholest-5-ene-3,26-diol |
| 供应商 | Tocris |
| 生物活性 | Liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 402.65 |
| 分子式 | C27H46O2 |
| 可溶性/溶解性 | Soluble to 20 mM in ethanol |
| 参考文献 | DuSellet al (2008) 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator Mol.Endocrinol. 22 65. PMID: 17872378. Rantham Prabhakaraet al (2008) Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and α-synuclein in human neuroblastoma SH-SY5Y cells. J.Neurochem. 107 1722. PMID: 19014385. Fuet al (2001) 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J.Biol.Chem. 276 38378. PMID: 11504730. |