Inflachromene
货号：
17006-5mg 基本售价：
4144.0 元 规格：
5 mg
产品信息
概述| 货号 | 17006-5mg |
| 描述 | Inflachromene is an anti-inflammatory agent that directly binds high mobility group protein 1 (HMGB1) and HMGB2 and reduces their cytoplasmic accumulation in microglial cells.1 It is functional in vivo, downregulating proinflammatory functions of HMGB proteins and reducing neuronal damage.1 Inflachromene also ameliorates inflammatory pathogenesis in a mouse model of sepsis.2 |
| 别名 | ICM; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lee, S.,Nam, Y.,Koo, J.Y., et al. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation. Nat. Chem. Biol. 10(12), 1055-1060 (2014).
2.Cho, W.,Koo, J.Y.,Park, Y., et al. Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents. J. Med. Chem. 60(1), 170-179 (2017).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 377.4 |
| 分子式 | C21H19N3O4 |
| CAS号 | 908568-01-4 |
| 稳定性 | ≥ 2 years |
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