货号 | 18473-1mg |
描述 | Fibrinogen is a plasma clotting factor composed of three different polypeptide chains (α, β and γ). Under chronic inflammatory conditions, fibrinogen can be acted upon by the peptidylarginine deiminases enzymes (PAD2 and PAD4), converting specific arginine residues to citrulline. Patients with rheumatoid arthritis (RA) produce antibodies that bind citrullinated human fibrinogen.1 The citrullinated fibrinogen and reactive antibodies form immune complexes in RA patients, and these immune complexes can stimulate macrophages.2,3 Immunizing certain strains of mice with citrullinated human fibrinogen can induce the production of anti-citrullinated human fibrinogen antibodies and the development of arthritis that shares many pathophysiological features of the human disease.4,5 |
供应商 | Cayman |
应用文献 | |
1.Hill, J.A.,Al-Bishri, J.,Gladman, D.D., et al. Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis. Journal of Rheumatology 33(11), 2115-2119 (2006). 2.Zhao, X.,Okeke, N.L.,Sharpe, O., et al. Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. Arthritis Research & Therapy 10(4), (2008). 3.Sokolove, J.,Zhao, X.,Chandra, P.E., et al. Immune complexes containing citrullinated fibrinogen costimulate macrophages via toll-like receptor 4 and Fcγ receptor. Arthritis and Rheumatism 63(1), 53-62 (2011). 4.Hill, J.A.,Bell, D.A.,Brintnell, W., et al. Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. Journal of Experimental Medicine 205(4), 967-979 (2008). 5.Yue, D.,Brintnell, W.,Mannik, L.A., et al. CTLA-4Ig blocks the development and progression of citrullinated fibrinogen-induced arthritis in DR4-transgenic mice. Arthritis and Rheumatism 62(10), 2941-2952 (2010). | |
运输条件 | Dry ice in continental US; may vary elsewhere |
存放说明 | -80 |
稳定性 | ≥ 2 years |
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