KC01
货号：
17364-1mg 基本售价：
4130.0 元 规格：
1 mg
产品信息
概述| 货号 | 17364-1mg |
| 描述 | ABHD16A (also known as HLA-B associated transcript 5 (BAT5)) is a phosphatidylserine hydrolase that regulates the formation of lysophosphatidylserines (lyso-PSs) and has been implicated in certain immunological and neurological diseases.1 KC01 is a covalent inhibitor of ABHD16A (IC50s = 90 and 520 nM for human and mouse, respectively).1 It has been shown to deplete lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and to decrease LPS-induced cytokine production in macrophages.1 This compound has been used to characterize the role of ABHD16A as a principle phosphatidylserine lipase in vivo.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kamat, S.S.,Camara, K.,Parsons, W.H., et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nature Chemical Biology 11, 164-175 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 365.6 |
| 分子式 | C22H39NO3 |
| CAS号 | 1646795-59-6 |
| 稳定性 | ≥ 1 year |
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