| 货号 | 10765-250ug |
| 描述 | Retinoblastoma protein-interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-finger motifs and 1 PR domain.1,2 The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-oncoprotein lacking the N-terminal PR domain containing the methyltransferase activity.3 When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.4 |
| 别名 | KMT8;PRDM2;PR Domain Zinc Finger Protein 2;Retinoblastoma Protein-interacting Zinc Finger Protein; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Buyse, I.M.,Shao, G. and Huang, S. The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proceedings of the National Academy of Sciences of the United States of America 92, 4467-4471 (1995). 2.Xie, M.,Shao, G.,Buyse, I.M., et al. Transcriptional repression mediated by the PR domain zinc finger gene RIZ. The Journal of Biological Chemisty 272(42), 26360-26366 (1997). 3.Liu, L.,Shao, G.,Steele-Perkins, G., et al. The retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter. The Journal of Biological Chemisty 272(5), 2984-2991 (1997). 4.Kim, K.C.,Geng, L. and Huang, S. Inactivation of a histone methyltransferase by mutations in human cancers. Cancer Research 63, 7619-7623 (2003). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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