Boceprevir
货号：
18379-25mg 基本售价：
4116.0 元 规格：
25 mg
产品信息
概述| 货号 | 18379-25mg |
| 描述 | Boceprevir is a protease inhibitor that covalently, yet reversibly, binds (Ki = 14 nM) to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication.1 It was shown to inhibit the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM.1 Boceprevir can inhibit the activity of recombinant HCV genotype 1a and 1b NS3/4A protease enzymes in vitro with Ki values of 14 nM for each subtype.2 It has been evaluated in phase III clinical studies in combination with the current standard of care for treatment of HCV.2 |
| 别名 | SCH 503034;Victrelis; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Malcolm, B.A.,Liu, R.,Lahser, F., et al. SCH 503034, a mechanism-based inhibitor of hepatitis C virus NS3 protease, suppresses polyprotein maturation and enhances the antiviral activity of alpha interferon in replicon cells. Antimicrobial Agents and Chemotherapy 50(3), 1013-1020 (2006).
2.Trembling, P.M.,Tanwar, S. and Dusheiko, G.M. Boceprevir: An oral protease inhibitor for the treatment of chronic HCV infection. Expert Rev.Anti.Infect.Ther. 10(3), 269-279 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 519.7 |
| 分子式 | C27H45N5O5 |
| CAS号 | 394730-60-0 |
| 稳定性 | ≥ 2 years |
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