Necrostatin-7
货号：
10528-25mg 基本售价：
4095.0 元 规格：
25 mg
产品信息
概述| 货号 | 10528-25mg |
| 描述 | Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand–induced and tumor necrosis factor-α (TNF-α) induced necrosis.1 Necrostatin-7 (Nec-7) is a necroptosis inhibitor that is structurally and biologically distinct from necrostatin-1, -3, -4, and -5 as it does not inhibit RIP1 kinase. Nec-7 may target an additional regulatory molecule in this pathway as it inhibits TNF-α-induced necroptosis in a FADD-deficient variant of human Jurkat T cells with an EC50 value of 10.6 μM.2 |
| 别名 | Nec-7; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Teng, X.,Degterev, A.,Jagtap, P., et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg. Med. Chem. Lett. 15(22), 5039-5044 (2005).
2.Zheng, W.,Degterev, A.,Hsu, E., et al. Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7. Bioorganic & Medicinal Chemistry Letters 18, 4932-4935 (2008).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 371.4 |
| 分子式 | C16H10FN5OS2 |
| CAS号 | 351062-08-3 |
| 稳定性 | ≥ 2 years |
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