| 货号 | 3380/50 |
| 别名 | N-(Benzylamidino)-3,5-diamino-6-chl |
| 供应商 | Tocris |
| 生物活性 | Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 356.21 |
| 分子式 | C13H14ClN7O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 10 mM in water |
| 参考文献 | Daiet al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576. PMID: 17804601. Pageet al (2007) Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain 133 150. PMID: 17467171. Fischeret al (2002) Characterization of a Na+-Ca2+ exchanger in podocytes. Nephrol.Dial.Transplant. 17 1742. PMID: 12270979. |