| 货号 | 13859-25mg |
| 描述 | The calpains are a family of calcium-dependent cysteine proteases which catalyze limited proteolysis of substrates.1 PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)).2 PD 150606 is commonly used to elucidate the roles for calpains in cell function, particularly in how they relate to apoptosis.3,4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sorimachi, H. and Ono, Y. Regulation and physiological roles of the calpain system in muscular disorders. Cardiovascular Research 96, 11-22 (2012). 2.Wang, K.K.W.,Nath, R.,Posner, A., et al. An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proceedings of the National Academy of Sciences of the United States of America 93, 6687-6692 (1996). 3.Muruganandan, S. and Cribb, A.E. Calpain-induced endoplasmic reticulum stress and cell death following cytotoxic damage to renal cells. Toxicological Sciences 94(1), 118-128 (2006). 4.Norberg, E.,Gogvadze, V.,Ott, M., et al. An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death. Cell Death and Differentiation 15, 1857-1864 (2008). 5.Debiasi, R.L.,Squier, M.K.T.,Pike, B., et al. Reovirus-induced apoptosis is preceded by increased cellular calpain activity and is blocked by calpain inhibitors. Journal of Virology 73(1), 695-701 (1999). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 306.1 |
| 分子式 | C9H7IO2S |
| CAS号 | 179528-45-1 |
| 稳定性 | ≥ 2 years |
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