EED (human recombinant)
货号：
10628-50ug 基本售价：
4060.0 元 规格：
50 ug
产品信息
概述| 货号 | 10628-50ug |
| 描述 | The human-Embryonic ectoderm development (EED) protein is a WD40 repeat-containing protein that forms part of the Polycomb repressive complex 2 (PRC2).1,2 The PRC2 core complex contains the catalytic subunit EZH2 (Enhancer of zeste 2), SUZ12 (Suppressor of zeste) and EED. The EED subunit does not contain methyltransferase activity. However, transcriptional repression by PRC2-mediated trimethylation of lysine 27 on Histone H3 (H3K27me3) has been shown to be dependent on EED binding to repressive histone marks.3 |
| 别名 | Embryonic Ectoderm Development; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schumacher, A.,Lichtarge, O.,Schwartz, S., et al. The murine polycomb-group gene EED and its human orthologue: Functional implications of evolutionary conservation. Genomics 54, 79-88 (1998).
2.Suganuma, T. and Workman, J.L. WD40 repeats arrange histone tails for spreading of silencing. J.Mol.Cell Biol. 2, 81-83 (2010).
3.Margueron, R.,Justin, N.,Ohno, K., et al. Role of the polycomb protein EED in the propagation of repressive histone marks. Nature 461, 762-767 (2009).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 9 months |
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