Soluble Epoxide Hydrolase (mouse recombinant)
货号：
10011670-50ug 基本售价：
4060.0 元 规格：
50 ug
产品信息
概述| 货号 | 10011670-50ug |
| 描述 | Mammalian soluble epoxide hydrolase (sEH) is a member of the α/β-hydrolase fold family of enzymes that catalyzes the hydrolysis of exogenous and endogenous epoxides to vicinal diols. sEH is a homodimer consisting of two domains.1 The C-terminal domain is responsible for the epoxide hydrolase activity while the N-terminal domain has a catalytic center with phosphatase activity. Endogenous substrates for sEH include epoxyeicosatrienoic acids (EETs) which are known for their vasodialatory effects as well as for their anti-inflammatory actions.2 Inhibition of sEH in animal models was shown to reduce hypertension and vascular inflammation, as well as related syndromes, validating sEH as a highly promising target for drug discovery.3 |
| 别名 | Cytosolic Epoxide Hydrolase (CEH);EPHX2;Epoxide Hydrolase 2;sEH; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chiamvimonvat, N.,Ho, C.M.,Tsai, H.J., et al. The soluble epoxide hydrolase as a pharmaceutical target for hypertension. Journal of Cardiovascular Pharmacology 50(3), 225-237 (2007).
2.Yu, Z.,Xu, F.,Huse, L.M., et al. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circulation Research 87, 992-998 (2000).
3.Imig, J.D.,Zhao, X.,Zaharis, C.Z., et al. An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension. Hypertension 46(2), 975-981 (2005).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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