| 货号 | 0421/50 |
| 别名 | 1-[2-[Bis-(4-fluorophenyl)methoxy]e |
| 供应商 | Tocris |
| 生物活性 | Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 523.49 |
| 分子式 | C28H32F2N2O.2HCl |
| 可溶性/溶解性 | Soluble to 5 mM in water with gentle warming and to 50 mM in DMSO |
| CAS号 | 67469-78-7 |
| 参考文献 | Spealman and Melia (1991) Pharmacological characterization of the discriminative-stimulus effects of GBR 12909. J.Pharmacol.Exp.Ther. 258 626. PMID: 1678014. Contreraset al (1990) GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain. Life Sci. 47 PL133. PMID: 1980329. Andersen (1989) The dopamine uptake inhibitor GBR12909: selectivity and molecular mechanism of action. Eur.J.Pharmacol. 166 493. PMID: 2530094. Heikkila and Manzino (1984) Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur.J.Pharmacol. 103 241. PMID: 6237922. |