PDD 00017273 ( )
货号：
5952/10 基本售价：
4005.4 元 规格：
10 mg
产品信息
概述| 货号 | 5952/10 |
| 别名 | 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM). Exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Maintains PAR chains and induces DNA double-stranded breaks in cells following DNA damage. Decreases colony formation of ZR-75-1 BRCA1 WT cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 514.62 |
| 分子式 | C23H26N6O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Jameset al (2016) First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib. ACS Chem.Biol.. PMID: 27689388. |
