货号 | 3402/1 |
别名 | N-[4-[(2R,4R,6S)-4-[[(4,5-Diphenyl- |
供应商 | Tocris |
生物活性 | Selective inhibitor of HDAC6; inhibits the second deacetylase domain (DD2). Does not inhibit HDAC6 histone deacetylase activity; reversibly inhibits α-tubulin deacetylation. Increases α-tubulin acetylation levels with no effect on histone acetylation or cell cycle progression. |
运输条件 | Blue Ice |
存放说明 | -20℃ |
纯度 | >98 % |
计算分子量 | 721.86 |
分子式 | C41H43N3O7 |
可溶性/溶解性 | Soluble to 10 mM in DMSO |
参考文献 | Jianget al (2008) Direct binding with histone deacetylase 6 mediates the reversible recruitment of parkin to the centrosome. J.Neurosci. 28 12993. PMID: 19036992. Haggartyet al (2003) Multidimensional chemical genetic analysis of diversity-orientated synthesis-derived deacetylase inhibitors using cell-based assays. Chem.Biol. 10 383. PMID: 12770821. Haggartyet al (2003) Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc.Natl.Acad.Sci.USA 100 4389. PMID: 12677000. |