| 货号 | 3224/10 |
| 别名 | (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Penta |
| 供应商 | Tocris |
| 生物活性 | Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro(IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >95 % |
| 计算分子量 | 658.76 |
| 分子式 | C34F43F5O5S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 151555-47-4 |
| 参考文献 | Amelleret al (2004) Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in estradiol-dependent cancers. J.Steroid Molec.Biol. 921. Mulleret al (1998) Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines. Cancer Res. 58 263. PMID: 9443403. Van de Veldeet al (1996) RU 58668: Further in vitroandin vivo pharmacological data related to its antitumoral activity. J.Steroid Molec.Biol. 59449. |