| 货号 | 2602/10 |
| 别名 | (S)-N-[[1-(5-Methoxy-2-pyridinyl)cy |
| 供应商 | Tocris |
| 生物活性 | Non-peptide gastrin-releasing peptide receptor (GRP-R, BB2) and neuromedin B receptor (NMB-R, BB1) antagonist (Ki values are 0.17 and 1.0 nM for BB1 and BB2 respectively). Inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 584.67 |
| 分子式 | C32H36N6O5 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 204067-01-6 |
| 参考文献 | Schepetkinet al (2011) Gastrin-releasing peptide/neuromedin B receptor antagonists pD176252, PD168368, and related analogs are potent agonists of human formyl-peptide receptors. Mol.Pharmacol. 79 77. PMID: 20943772. Moodyet al (2003) Nonpeptide gastrin releasing peptide receptor antagonists inhibit the proliferation of lung cancer cells Eur.J.Pharmacol. 474 21. PMID: 12909192. Moodyet al (2000) Nonpeptide neuromedin B receptor antagonists inhibit the proliferation of C6 cells Eur.J.Pharmacol. 409 133. PMID: 11104826. Ashwoodet al (1998) PD 176252 - the first high affinity non-peptide gastrin-releasing peptide (BB2) receptor antagonist Bioorg.Med.Chem.Lett. 8 2589. PMID: 9873586. |