| 货号 | 2628/10 |
| 别名 | N-[(1S,3S)-1-[(Ethoxymethoxy)methyl |
| 供应商 | Tocris |
| 生物活性 | Broad spectrum MMP inhibitor; Ki values are 0.45, 0.73, 1.1, 1.1, 2.1, 42 and 2500 nM for MMP-12, MMP-2, MMP-8, MMP-13, MMP-9, MMP-3 and MMP-7 respectively and IC50 = 1600 nM for MMP-1). Displays no activity at other proteases up to a concentration of 100 μM. Exhibits antiangiogenic and anti-invasive properties on lung metastasis of murine renal cell carcinoma. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 416.47 |
| 分子式 | C22H28N2O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| CAS号 | 223472-31-9 |
| 参考文献 | Medina and Radomski (2006) Role of matrix metalloproteinases in intestinal inflammation. J.Pharmacol.Exp.Ther. 318 933. PMID: 16644899. Muraishiet al (2001) Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma. Anticancer Res. 21 3845. PMID: 11911256. Yamadaet al (2000) ONO-4817, an orally active matrix metalloproteinase inhibitor, prevents lipopolysaccharide-induced proteoglycan release from the joint cartilage in guinea pigs. Inflamm.Res. 49 144. PMID: 10858013. |