| 货号 | 1655/10 |
| 别名 | (6aR,10aR)-1-Hydroxy-3-(1-Methanesu |
| 供应商 | Tocris |
| 生物活性 | Originally defined as a high affinity cannabinoid CB1 receptor silent antagonist. Acts as a partial agonist in inhibiting forksolin-induced cyclic AMP stimulation (EC50 = 40.4 nM). Decreases food intake and stimulates locomotor activity in rodents. Antagonizes effects of CP55,940 (Cat. No. 0949) in vitro. |
| 运输条件 | Dry Ice |
| 存放说明 | -80℃ |
| 纯度 | >97 % |
| 计算分子量 | 417.56 |
| 分子式 | C23H31NO4S |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| 参考文献 | Wileyet al (2011) Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB1 receptor antagonist. Eur.J.Pharmacol. 651 96. PMID: 21114999. Gardner and Mallet (2006) Suppression of feeding, drinking, and locomotion by a putative cannabinoid receptor 'silent antagonist.' Eur.J.Pharmacol. 530 103. PMID: 16380113. Martinet al (2002) Agonists and silent antagonists in a series of cannabinoid sulfonamides. Symposium on the Cannabinoids, International Canna. |