| 货号 | 3061/1 |
| 别名 | (15R)-6,17-Didemethoxy-15-methoxy-6 |
| 供应商 | Tocris |
| 生物活性 | Ansamycin antibiotic compound that inhibits Hsp90 activity (IC50 = 2 μM) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC50 ~ 0.4 μM) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (Cat. No. 1368). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 558.67 |
| 分子式 | C30H42N2O8 |
| 可溶性/溶解性 | Soluble in DMSO |
| CAS号 | 73341-72-7 |
| 参考文献 | Martinet al (2008) Molecular characterization of macbecin as an Hsp90 inhibitor. J.Med.Chem. 51 2853. PMID: 18357975. Ueharaet al (2003) Natural product origins of Hsp90 inhibitors. Curr.Cancer Drug Targets 3 325. PMID: 14529384. Onoet al (1982) Antitumor and cytocidal activities of a newly isolated benzenoid ansamycin, macbecin I. Gann. 73 938. PMID: 6186564. |