| 货号 | 2145/100U |
| 供应商 | Tocris |
| 生物活性 | Dimeric version of R18 peptide (Cat. No. 2144) that binds to 14.3.3 proteins with high affinity. Competitively inhibits 14.3.3-ligand interactions; blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S. Induces apoptosis when expressed in COS-7 and various cancer cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 6387.17 |
| 分子式 | C273H424N76O |
| 可溶性/溶解性 | Soluble to 5 mg/ml in water |
| 序列号 | SADGAPHCVPRDLSWLDLEANMCLPGAAGL |
| 参考文献 | Hermeking (2003) The 14.3.3 cancer connection. Nature Rev.Cancer 3931. Masterset al (2002) Survival-promoting functions of 14.3.3 proteins. Biochem.Soc.Transactions 30360. Masters and Fu (2001) 14.3.3 proteins mediate an essential anti-apoptotic signal. J.Biol.Chem. 276 45193. PMID: 11577088. |