| 货号 | 3945/500U |
| 供应商 | Tocris |
| 生物活性 | Neuroprotective peptide and activator of STAT3. Protects neurons against the neurotoxic effects of amyloid β-peptide (1-43) at a concentration of 100 fM in vitro. Suppresses neuronal death by activating STAT3 in vitro; upregulates cholinergic transmission and ameliorates memory impairment in Alzheimer's disease (AD) models. Also prevents alcohol-induced apoptosis in a fetal mouse model. Brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2645.13 |
| 分子式 | C119H206N32O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 20% ethanol / water |
| 序列号 | SALLRSIPAPAGASRLLLLTGEIDLP |
| 参考文献 | Sariet al (2009) A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations. Neuroscience 164 1653. PMID: 19782727. Yamadaet al (2008) Nasal colivelin treatment ameliorates memory impairment related to Alzheimer's disease. Neuropsychopharmacology 33 2020. PMID: 17928813. Chibaet al (2005) Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitroandin vivo. J.Neurosci. 25 10252. PMID: 16267233. |