L3MBTL1 MBT domains (human recombinant; GST-tagged)【科瑞奥博】

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L3MBTL1 MBT domains (human recombinant; GST-tagged)

货号： 14775-100ug 基本售价： 3990.0 元规格： 100 ug

产品信息

概述
货号	14775-100ug
描述	*Key Features* Cayman’s L3MBTL1 MBT Domains TR-FRET Assay Kit (Item No. 601030) was developed using L3MBTL1 MBT domains (human recombinant; GST-tagged) protein. Bulk sizes available upon request "The malignant brain tumor (MBT) domain is structurally related to chromatin binding domains, such as chromodomains, tudor domains, and PWWP-domains.^1,2 MBT domain-containing proteins have a variable number of MBT repeats. The MBT domains recognize methylated lysines on histone tails with varying degree of specificity for the various methyl marks.¹L3MBTL1, a human homolog of the Drosophila lethal(3)MBT protein, is a member of the polycomb group (PcG) of proteins that functions as a transcriptional repressor.³ L3MBTL1 contains three MBT repeat domains which collectively bind to either histone H3 or H4.^1,4 The second and third MBT domains were found to bind preferentially to mono- and dimethylated lysines of histone H3 at lysine 4 (H3K4me1) and histone H4 at lysine 20 (H4K20me2).^4,5 Recognition of methyl-lysine marks by MBT domains leads to chromatin compaction and a repressed transcriptional state.^4,6 Further, L3MBTL1 has a tumor suppressor function and is thought to play a role in maintaining genomic stability and DNA replication.^7,8This protein product contains the MBT repeat region of L3MBTL1."
别名	H-l(3)MBT;Lethal(3)Malignant Brain Tumor-like Protein 1;L(3)MBT-like;

性能
供应商	Cayman
应用文献
1.Trojer, P. and Reinberg, D. Beyond histone methyl-lysine binding: How malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure. Cell Cycle 7(5), 578-585 (2008). 2.Maurer-Stroh, S.,Dickens, N.J.,Hughes-Davies, L., et al. The Tudor domain Royal Family: Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends in Biochemical Sciences 28(2), 69-74 (2003). 3.Boccuni, P.,MacGrogan, D.,Scandura, J.M., et al. The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). The Journal of Biological Chemisty 278(17), 15412-15420 (2003). 4.Trojer, P.,Li, G.,Sims, R.J., III, et al. L3MBTL1, a histone-methylation-dependent chromatin lock. Cell 129(5), 915-928 (2007). 5.Kim, J.,Daniel, J.,Espejo, A., et al. Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO reports 7(4), 397-403 (2006). 6.Kalakonda, N.,Fischle, W.,Boccuni, P., et al. Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. Oncogene 27(31), 4293-4304 (2008). 7.Acs, K.,Luijsterburg, M.S.,Ackermann, L., et al. The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks. Nature Structural & Molecular Biology 18(12), 1345-1350 (2011). 8.Gurvich, N.,Perna, F.,Farina, A., et al. L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability. Proceedings of the National Academy of Sciences of the United States of America 107(52), 22552-22557 (2010).
运输条件	Dry ice in continental US; may vary elsewhere
存放说明	-80
纯度	≥90% estimated by SDS-PAGE
稳定性	≥ 1 year

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