| 货号 | 14769-100ug |
| 描述 | CBX2 is a component of the polycomb repressive complex 1 and represses protein expression.1 The chromodomain regions of CBX2 recognizes histone H3 trimethyl lysine 9 (H3K9me3) or trimethyl lysine 27 (H3K27me3).2,3,4 CBX2 knock-out mice have impaired spleen formation, T cell expansion, and inactivation of the X chromosome, which can be lethal in some cases.5 This protein product contains the chromodomain region of CBX2. |
| 别名 | CDCA6;Cell Division Cycle Associated 6;Chromobox Protein Homolog 2 (Drosophila Pc Class);M33;MGC10561;Modifier 3;SRXY5; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schoorlemmer, J.,Marcos-Gutiérrez, C.,Were, F., et al. Ring1A is a transcriptional repressor that interacts with the Polycomb-M33 protein and is expressed at rhombomere boundaries in the mouse hindbrain. EMBO Journal 16(19), 5930-5942 (1997). 2.Nielsen, A.L.,Oulad-Abdelghani, M.,Ortiz, J.A., et al. Heterochromatin formation in mammalian cells: Interaction between histones and HP1 proteins. Mol.Cell. 7(4), 729-739 (2001). 3.Bernstein, E.,Duncan, E.M.,Masui, O., et al. Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol.Cell Biol. 26(7), 2560-2569 (2006). 4.Kaustov, L.,Ouyang, H.,Amaya, M., et al. Recognition and specificity determinants of the human Cbx chromodomains. The Journal of Biological Chemisty 286(1), 521-529 (2011). 5.Katoh-Fukui, Y.,Owaki, A.,Toyama, Y., et al. Mouse polycomb M33 is required for splenic vascular and adrenal gland formation through regulating Ad4BP/SF1 expression. Blood 106(5), 1612-1620 (2005). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥90% |
| 稳定性 | ≥ 6 months |
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