Withaferin A
货号：
11352-5mg 基本售价：
3990.0 元 规格：
5 mg
产品信息
概述| 货号 | 11352-5mg |
| 描述 | Upregulation of vimentin expression is one of the hallmarks of the epithelial-mesenchymal transition that accompanies the transformation of pre-metastatic to metastatic cancer cells. Withaferin A is a steroidal lactone present in W. somnifera that at 2-25 μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts, causing apoptosis.1,2 As such, it has been proposed as an anti-tumor agent to target metastatic cells that upregulate vimentin expression. At 2 mg/kg, withaferin A exhibits potent inhibition of angiogenesis in a mouse model of injury-induced corneal neovascularization.1 Withaferin A can also induce perinuclear aggregates in other intermediate filament networks including peripherin, neurofilament-triplet protein, and keratin as well as disrupt the organization of microtubules and actin/microfilaments.2 |
| 别名 | NSC 101088;NSC 273757; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bargagna-Mohan, P.,Hamza, A.,Kim, Y.e., et al. The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin. Chemistry & Biology 14(6), 623-634 (2007).
2.Grin, B.,Mahammad, S.,Wedig, T., et al. Withaferin A alters intermediate filament organization, cell shape and behavior. PLoS One 7(6), 1-13 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 470.6 |
| 分子式 | C28H38O6 |
| CAS号 | 5119-48-2 |
| 稳定性 | ≥ 2 years |
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