CREB-binding protein bromodomain (human recombinant)
货号：
11288-100ug 基本售价：
3990.0 元 规格：
100 ug
产品信息
概述| 货号 | 11288-100ug |
| 描述 |
Key Features
- Cayman’s CBP bromodomain TR-FRET Assay Kit (Item No. 600850) was developed using CREB-binding protein bromodomain (human recombinant) protein.
- Bulk sizes available upon request
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. Acetylated lysine residues are recognized by a small protein domain known as a bromodomain.1 These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters.2 The cAMP response element-binding protein (CREB) binding protein (CREBBP) bromodomain has been shown to modulate the stability and function of the tumor suppressor protein p53. CREBBP bromodomain recognizes the acetylated lysine residue 382 on p53.3,4 This product contains the bromodomain region of CREBBP.2 |
| 别名 | cAMP-Response Element-binding Protein 1 CREB-1;CBP;CREBBP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mujtaba, S.,Zeng, L. and Zhou, M.M. Structure and acetyl-lysine recognition of the bromodomain. Oncogene 26, 5521-5527 (2011).
2.Muller, S.,Filippakopoulos, P. and Knapp, S. Bromodomains as therapeutic targets. Expert Rev.Mol.Med. 13, 1-21 (2011).
3.Sachchidanand, L.R.S.,Yan, S.,Mutjaba, S., et al. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chemistry & Biology 13, 81-90 (2006).
|
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥91% estimated by SDS-PAGE |
| 稳定性 | ≥ 1 year |
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