| 货号 | 11287-100ug |
| 描述 | DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding protein 2 (MeCP2) specifically binds to methylated promoters on CpG islands and mediates gene silencing by recruiting corepressor complexes.1 The Methyl-CpG Binding Domain (MBD) protein family consists of five members: MeCP2, MBD1, MBD2, MBD3 and MBD4.2,3,4 The sequence similarity between the MBD proteins is limited to the MBD domains.5 In vitro work suggests high affinity binding of MeCP2 is facilitated by DNA fragments containing A/T bases ([A/T]≥4) adjacent to the methyl-CpG.6 Mutations in the MeCP2 gene have been linked to the X-linked neurological disorder, Rett Syndrome.7 |
| 别名 | Methyl-CpG Binding Protein 2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ho, K.L.,McNae, I.W.,Schmiedeberg, L., et al. MeCP2 binding to DNA depends upon hydration at methyl-CpG. Molecular Cell 29, 525-531 (2008). 2.Fatemi, M. and Wade, P.A. MBD family proteins: Reading the epigenetic code. Journal of Cell Science 119, 3033-3037 (2006). 3.Dhasarathy, A. and Wade, P.A. The MBD protein family-reading an epigenetic mark? Mutation Research 647, 39-43 (2008). 4.Hendrich, B. and Bird, A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Molecular and Cellular Biology 18(11), 6538-6547 (1998). 5.Berger, J. and Bird, A. Role of MBD2 in gene regulation and tumorigenesis. Biochemical Society Transactions 33, 1537-1540 (2005). 6.Klose, R.J.,Sarraf, S.A.,Schmiedeberg, L., et al. DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG. Molecular Cell 19, 667-678 (2005). 7.Zachariah, R.M. and Rastegar, M. Linking epigenetics to human disease and Rett Syndrome: The emerging novel and challenging concepts in MeCP2 research. Neural Plast. 1-10 (2012). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 稳定性 | ≥ 1 year |
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