| 货号 | 11286-100ug |
| 描述 | DNA methylation occurs mainly at the 5’-position of cytosine rings (5-methylcytosine (5mC)). The 5mC bases are found largely in genomic regions with a high frequency of cytosines and guanines, called CpG islands. Methyl-CpG binding domain 2 (MBD2) protein specifically binds to methylated promoters on CpG islands. The MBD protein family consists of five members: MeCP2, MBD1, MBD2, MBD3, and MBD4.1,2,3 The sequence similarity between the MBD proteins is limited to the MBD domains.4 MBD2 binding to 5mC facilitates the recruitment of chromatin remodeling and transcriptional repressor complexes, which results in a repressive chromatin state.5,4 MBD2 has been implicated in breast cancer progression. Silencing of MBD2 protein expression was found to be sufficient to initiate and maintain tumor suppressor gene transcription.6 |
| 别名 | Methyl-CpG Binding Domain Protein 2;Methyl Cytosine Binding Domain Protein 2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fatemi, M. and Wade, P.A. MBD family proteins: Reading the epigenetic code. Journal of Cell Science 119, 3033-3037 (2006). 2.Dhasarathy, A. and Wade, P.A. The MBD protein family-reading an epigenetic mark? Mutation Research 647, 39-43 (2008). 3.Hendrich, B. and Bird, A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Molecular and Cellular Biology 18(11), 6538-6547 (1998). 4.Berger, J. and Bird, A. Role of MBD2 in gene regulation and tumorigenesis. Biochemical Society Transactions 33, 1537-1540 (2005). 5.Ng, H.H.,Zhang, Y.,Hendrich, B., et al. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Nature Genetics 23, 58-61 (1999). 6.Mian, O.Y.,Wang, S.Z.,Zhu, S.Z., et al. Methyl binding domain protein 2 (MBD2) dependent proliferation and survival of breast cancer cells. Molecular Cancer Research 9(8), 1152-1162 (2011). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% |
| 稳定性 | ≥ 1 year |
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