| 货号 | 13204-1mg |
| 描述 | Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate Hedgehog homologs, and is essential for proper embryonic development.1 Shh binds to its receptor, Patched (Ptch1), resulting in the de-repression of Smoothened.2,3 This leads to the activation of Gli2, which regulates the transcription of target genes that include Gli1 and Ptch1. Robotnikinin is the first identified small molecule inhibitor of Shh signaling that acts upstream of Smo, binding directly to Shh with a Kd value of 3.1 μM.4,5 Robotnikinin represses Gli-mediated transcription in primary human keratinocytes and synthetic human skin in a concentration-dependent manner.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Heretsch, P.,Tzagkaroulaki, L. and Giannis, A. Cyclopamine and hedgehog signaling: Chemistry, biology, medical perspectives. Angewandte Chemie International Edition 49, 3418-3427 (2010). 2.Stone, D.M.,Hynes, M.,Armanini, M., et al. The tumour-suppressor gene patched encodes a candidate receptor for sonic hedgehog. Nature 384, 129-133 (1996). 3.Rohatgi, R.,Milenkovic, L.,Corcoran, R.B., et al. Hedgehog signal transduction by smoothened: Pharmacologic evidence for a 2-step activation process. Proceedings of the National Academy of Sciences of the United States of America 106(9), 3196-3201 (2009). 4.Stanton, B.Z.,Peng, L.F.,Maloof, N., et al. A small molecule that binds hedgehog and blocks its signaling in human cells. Nature Chemical Biology 5(3), 154-156 (2009). 5.Stanton, B.Z. and Peng, L.F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Molecular BioSystems 6(1), 44-54 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 455 |
| 分子式 | C25H27ClN2O4 |
| CAS号 | 1132653-79-2 |
| 稳定性 | ≥ 1 year |
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