Rp-8-CPT-Cyclic AMP (sodium salt)
货号：
17142-1mg 基本售价：
3962.0 元 规格：
1 mg
产品信息
概述| 货号 | 17142-1mg |
| 描述 | Rp-8-CPT-cAMP is a structural combination of the lipophilic and non-hydrolyzable cAMP analogs, 8-CPT-cyclic AMP (Item No. 12011) and Rp-cyclic AMPS (Item No. 16985).1 It functions as a site-selective inhibitor of protein kinase A (PKA) type I and II, with preference towards site A of type I and site B of type II.2 By occupying cAMP binding sites at the regulatory subunit of PKA, Rp-8-CPT-cAMP prevents the kinase holoenzyme from dissociative activation.2,3 |
| 别名 | Rp-8-CPT-cAMP; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schwede, F.,Maronde, F.,Genieser, H., et al. Cyclic nucleotide analogs as biochemical tools and prospective drugs. Pharmacology & Therapeutics 87(2), 199-226 (2000).
2.Dostmann, W.R.,Taylor, S.S.,Genieser, H.G., et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3,5-cyclic phosphorothioates. J. Biol. Chem. 265(18), 10484-10491 (1990).
3.Gjertsen, B.T.,Mellgran, G.,Otten, A., et al. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1β action. J. Biol. Chem. 270(35), 20599-20607 (1995).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 509.8 |
| 分子式 | C16H14ClN5O5PS2 • Na |
| CAS号 | 221905-35-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
