Ganglioside GD3 (sodium salt)
货号：
17481-1mg 基本售价：
3960.0 元 规格：
1 mg
产品信息
概述| 货号 | 17481-1mg |
| 描述 | Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer.1 Furthermore, the intracellular accumulation of ganglioside GD3 can contribute to mitochondrial damage, a crucial event during apoptosis.2 Ganglioside GD3 has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma.1,3 |
| 别名 | Disialosyllactosylceramide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hamamura, K.,Furukawa, K.,Hayashi, T., et al. Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proceedings of the National Academy of Sciences of the United States of America 102(31), 11041-11046 (2005).
2.De Maria, R.,Lenti, L.,Malisan, F., et al. Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. Science 277, 1652-1655 (1997).
3.Nicoll, G.,Avril, T.,Lock, K., et al. Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. European Journal of Immunology 33(6), 1642-1648 (2003).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 1516.7 |
| 分子式 | C70H123N3O29 • 2Na |
| CAS号 | 62010-37-1 |
| 稳定性 | ≥ 2 years |
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