| 货号 | 5196/1 |
| 供应商 | Tocris |
| 生物活性 | Potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer's Disease. Orally active and brain penetrant. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 839.05 |
| 分子式 | C45H62N10O6< |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | XPXWR (Modifications: X-1 = N2-(1-Oxo-3-phenylpropyl)-Orn, |
| 参考文献 | Jainet al (2013) The C5a receptor antagonist PMX205 ameliorates experimentally induced colitis associated with increased IL-4 and IL-10. Br.J.Pharmacol. 168 488. PMID: 22924972. Fonsecaet al (2009) Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J.Immunol. 183 1375. PMID: 19561098. Marchet al (2004) Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity. Mol.Pharmacol. 65 868. PMID: 15044616. |