| 货号 | 5213/1 |
| 供应商 | Tocris |
| 生物活性 | Antimicrobial peptide derivative of human cathelicidin. Induces FPRL1-mediated chemotaxis of human neutrophils, monocytes and T cells in vitro. Promotes wound healing following skin-targeted electroporation of a plasmid encoding hCAP-18/LL-37 in mice. Also triggers apoptosis in colon cancer cells. Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4493.32 |
| 分子式 | C205H340N60O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | LLGDFFRKSKEKIGKEFKRIVQRIKDFLRN |
| 参考文献 | Steinstraesseret al (2014) Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. Mol.Ther. 22 734. PMID: 24394186. Renet al (2012) Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer. Cancer Res. 72 6512. PMID: 23100468. Seilet al (2010) Spotlight on human LL-37, an immunomodulatory peptide with promising cell-penetrating properties. Pharmaceuticals 33435. Yanget al (2000) LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J.Exp.Med. 192 1069. PMID: 11015447. |